Anaphylaxis Overdose Recognition & Response

Anaphylaxis is a severe, potentially life-threatening allergic reaction that can occur rapidly after exposure to an allergen. Anaphylaxis is a medical emergency that requires immediate recognition and response to prevent serious health consequences or death. Understanding the signs, symptoms, and appropriate responses to anaphylaxis is crucial, especially for those who work in environments where they may encounter individuals at risk.

Recognition of Anaphylaxis

Early Symptoms: Anaphylactic reactions often begin with a sense of unease, followed by characteristic signs and symptoms that typically occur within minutes to hours after exposure to the allergen. Initial symptoms may include a runny nose, skin rash, or a feeling of warmth. As the reaction progresses, more severe symptoms appear.

Skin Manifestations: One of the most common signs of anaphylaxis is skin involvement, such as hives (urticaria), itching (pruritus), and flushing or paleness. Swelling (angioedema) can also occur, particularly around the eyes, lips, and face.

Respiratory Complications: Respiratory symptoms are indicative of airway involvement and can rapidly progress. These may include wheezing, coughing, shortness of breath, and a tight feeling in the chest. In severe cases, there can be a significant reduction in airway diameter, leading to stridor or a complete blockage that prevents breathing.

Cardiovascular Issues: Anaphylaxis can cause a sudden drop in blood pressure (hypotension), leading to symptoms like dizziness, lightheadedness, or fainting. A rapid, weak pulse and heart palpitations are also common. In extreme situations, anaphylaxis can lead to shock and loss of consciousness.

Gastrointestinal Symptoms: Some individuals may experience nausea, vomiting, diarrhea, or abdominal pain, which are signs that the gastrointestinal system is affected.

Neurological Effects: A sense of impending doom, confusion, or agitation can be neurological manifestations of anaphylaxis.

Risk Factors

Individuals with a history of allergies or previous anaphylactic reactions are at a higher risk. Additionally, people with asthma or certain conditions like mast cell disorders are more prone to severe reactions. Having one episode of anaphylaxis increases the risk of having another, so it is essential for these individuals and those around them to be well-versed in recognizing and responding to symptoms.

Response to Anaphylaxis

Immediate Action: The first and most critical step in responding to anaphylaxis is to call emergency medical services (EMS). Time is a critical factor, and the sooner professional help is initiated, the better the outcome can be.

Administer Epinephrine: If an epinephrine auto-injector is available, it should be administered as soon as possible. Epinephrine is the first-line treatment for anaphylaxis and can reverse symptoms by reducing swelling, stimulating the heart, and opening up the airways. Instructions are usually found on the device, and it is designed to be used even by non-healthcare professionals.

Position the Person Correctly: While waiting for EMS, the person should be laid flat on their back with their legs elevated to promote blood flow to vital organs. If breathing is difficult, they should sit up to make breathing easier. If vomiting occurs, turn the person on their side to prevent choking.

Do Not Give Oral Medication: Avoid giving any oral medications or fluids if the person is having difficulty breathing, as this can increase the risk of choking.

Continuous Monitoring: Monitor the person’s breathing and pulse. Be prepared to initiate CPR if the person stops breathing or if a pulse is no longer detectable.

Secondary Medications: After epinephrine, other medications like antihistamines and corticosteroids can be given, but these are secondary and should not delay the administration of epinephrine.

Avoidance of Triggers: After an anaphylactic event, identification, and avoidance of the specific allergen is crucial. The individual should also consult an allergist for further evaluation and management, which may include desensitization therapies or preventive strategies.

Education and Prevention

Preventing anaphylaxis is about managing risk. Individuals at risk should be educated on avoiding known allergens, recognizing early signs of a reaction, and responding appropriately. They should carry an epinephrine auto-injector at all times and consider wearing a medical alert bracelet that identifies their condition.

For organizations and institutions, training staff in the recognition and first aid response to anaphylaxis can save lives. Having an action plan in place and ensuring quick access to epinephrine auto-injectors in public places, like schools and restaurants, is also vital.


Anaphylaxis is a rapid and severe allergic reaction that necessitates swift recognition and an immediate, effective response. By understanding the signs and symptoms, knowing